Keynote Lecture in the 13th Japanese Society of Immunotoxicology (JSIT 2006) -Pathophysiological Development and Immunotoxicology: what we have found from research related to silica and silicate such as asbestos-

• OTSUKI Takemi

  Department of Hygiene, Kawasaki Medical School President of the 13th annual meeting of JSIT 2006

• MIURA Yoshie

  Department of Hygiene, Kawasaki Medical School Present address: Eppley Institute for Cancer Research, University of Nebraska Medical Center

• MAEDA Megumi

  Department of Hygiene, Kawasaki Medical School

• HAYASHI Hiroaki

  Department of Hygiene, Kawasaki Medical School

• MURAKAMI Shuko

  Department of Hygiene, Kawasaki Medical School

• DONG Maolong

  Department of Hygiene, Kawasaki Medical School Department of Plastic Surgery, Kawasaki Medical School

• NISHIMURA Yasumitsu

  Department of Hygiene, Kawasaki Medical School

Bibliographic Information

Other Title

• Keynote Lecture in the 13th Japanese Society of Immunotoxicology (JSIT 2006)
• —Pathophysiological Development and Immunotoxicology: what we have found from research related to silica and silicate such as asbestos—

Abstract

Silica and silicates may disturb immune functions such as autoimmunity and tumor immunity, because people who are exposed to the materials sometimes develop autoimmune and malignant diseases, respectively. Although silica-induced disorders of autoimmunity have been explained as adjuvant-type effects of silica, more precise analyses are needed and should reflect the recent progress in immunomolecular findings. A brief summary of our investigations related to the immunological effects of silica/asbestos is presented. Recent advances in immunomolecular studies led to detailed analyses of the immunological effects of asbestos and silica. Both affect immuno-competent cells and these effects may be associated with the pathophysiological development of complications in silicosis and asbestos-exposed patients such as the occurrence of autoimmune disorders and malignant tumors, respectively. In addition, immunological analyses may lead to the development of new clinical tools for the modification of the pathophysiological aspects of diseases such as the regulation of autoimmunity or tumor immunity using cell-mediated therapies, various cytokines, and molecule-targeting therapies. In particular, as the incidence of asbestos-related malignancies is increasing and such malignancies have been a medical and social problem since the summer in 2005 in Japan, efforts should be focused on developing a cure for these diseases to eliminate the nation wide anxiety about these malignancies.<br>

Journal

• Environmental Health and Preventive Medicine

  Environmental Health and Preventive Medicine 12 (4), 153-160, 2007

  The Japanese Society for Hygiene

Keywords

• silica
• asbestos
• immunology Fas
• regulatory T cell
• apoptosis

Details

• CRID: 1390001204459254144
• NII Article ID: 110006386435
• NII Book ID: AA1108348X
• DOI: 10.1265/ehpm.12.153
• ISSN: 13474715
• ISSN: 1342078X
• Web Site: https://search.jamas.or.jp/link/ui/2008017598
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed