口腔内腫瘤と多発性骨溶解を伴った犬の非定型リンパ腫の一例 A Case of Atypical Canine Lymphoma with Oral Mass and Multiple Osteolysis

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Abstract

8歳齢、避妊雌のゴールデンレトリバーに口腔腫瘤と跛行を認めた。全身骨格に骨溶解像が存在したが、血清および尿蛋白の電気泳動像では異常蛋白を認めなかった。口腔腫瘤組織検査では異型の骨髄球様異型細胞の増殖を認め、骨髄にも同様の異型細胞が浸潤していることが疑われた。これらの異型細胞群はペルオキシダーゼ染色、非特異的エステラーゼ染色共に陰性であり、PCR法によるリンパ球抗原受容体遺伝子再構成解析からBリンパ球系細胞のクローン性増殖が確認された。本症例を非定型リンパ腫と診断し、多剤併用化学療法を行ったところ口腔腫瘤は縮小し、多発性骨溶解も改善した。

An 8-year-old female Golden Retriever had an oral mass and lameness. Multiple osteolysis of the systemic skeleton without monoclonal gammopathy was shown on electrophoresis of serum and urine samples. Cytological and histopathological examinations of the oral mass revealed atypical polymorphic cells similar to myeloid cells, and bone marrow aspiration indicated that these abnormal cells also might have invaded the bone marrow. These cells were negative to peroxidase and non-specific esterase staining, and clonal expansion of B lymphocytes could be detected by polymerase chain reaction (PCR) assay for antigen receptor gene rearrangement. The case was diagnosed as atypical lymphoma and treated by multi-drug chemotherapy. On the 142nd day after the first admission, the case had remission and the oral mass and multiple osteolysis were improved.

Journal

  • The journal of veterinary medical science

    The journal of veterinary medical science 69(9), 977-980, 2007-09-25

    Japanese Society of Veterinary Science

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Keywords

Codes

  • NII Article ID (NAID)
    110006388659
  • NII NACSIS-CAT ID (NCID)
    AA10796138
  • Text Lang
    ENG
  • Article Type
    NOT
  • ISSN
    09167250
  • NDL Article ID
    8955616
  • NDL Source Classification
    ZR22(科学技術--農林水産--畜産)
  • NDL Call No.
    Z18-350
  • Data Source
    CJP  NDL  NII-ELS  IR 
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