Oxidative DNA Damage Estimated by Plasma 8‐hydroxydeoxyguanosine (8‐OHdG): Influence of 4, 4'‐methylenebis (2‐chloroaniline) Exposure and Smoking

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  • Chen Hong-I
    Division of Urology, Department of Surgery, Tri-Service General Hospita, National Defense Medical Center
  • Liou Saou-Hsing
    Department of Public Health, National Defense Medical Center Division of Environmental Health and Occupational Medicine, National Health Research Institutes
  • Ho Shu-Fen
    Department of Public Health, National Defense Medical Center
  • Wu Kuen-Yuh
    Division of Environmental Health and Occupational Medicine, National Health Research Institutes
  • Sun Chien-Wen
    Division of Environmental Health and Occupational Medicine, National Health Research Institutes
  • Chen Ming-Fong
    Division of Environmental Health and Occupational Medicine, National Health Research Institutes
  • Cheng Li-Chuan
    Division of Environmental Health and Occupational Medicine, National Health Research Institutes
  • Shih Tung-Sheng
    Institute of Occupational Safety and Health, Council of Labor Affairs and China Medical University and Hospital
  • Loh Ching-Hui
    Department of Family Medicine & Internal Medicine, Tri-Service General Hospital, National Defense Medical Center

書誌事項

タイトル別名
  • Oxidative DNA Damage Estimated by Plasma 8-hydroxydeoxyguanosine (8-OHdG): Influence of 4, 4'-methylenebis (2-chloroaniline) Exposure and Smoking
  • Oxidative DNA damage estimated by plasma 8-hydroxydeoxyguanosine (8-OHdG): influence of 4, 4′-methylenebis (2-chloroaniline) exposure and smoking
  • damage estimated by plasma 8-hydroxydeoxyguanosine (8-OHdG): influence of 4,4′-methylenebis (2-chloroaniline) exposure and smoking

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抄録

Oxidative DNA damage may play an important role in the human carcinogenic process. Recently, we reported a case of bladder cancer among 4, 4'-methylenebis (2-chloroaniline) (MBOCA)-exposed workers. By measuring the plasma level of 8-hydroxydeoxyguanosine (8-OHdG), we investigated the association between oxidative DNA damage and MBOCA exposure. In addition, we examined the effects of different confounders on the plasma level of 8-OHdG. We undertook a cross-sectional survey at four MBOCA-producing factories in Taiwan (158 subjects). Plasma 8-OHdG levels and urinary MBOCA concentrations were measured by liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS). Personal characteristics were collected by questionnaire. The workers were classified according to their job titles as exposed (n=57) or unexposed (n=101) groups as well as classified according to urinary MBOCA levels as high urinary MBOCA (>20 μg/g creatinine) (n=45) or low urinary MBOCA (n=108) groups. Neither the MBOCA-exposed workers nor the high urinary MBOCA workers had a significant increase in the mean plasma 8-OHdG level, even after adjustment for potential confounders. Age and gender were significantly positively correlated with plasma 8-OHdG levels. Smokers among high urinary MBOCA workers also had significantly higher 8-OHdG levels than non-smokers among high urinary MBOCA workers. Our study provides evidence that smoking rather than MBOCA exposure induces elevation of plasma 8-OHdG levels among workers exposed to MBOCA, indicating that oxidative DNA damage does not play an important role in the carcinogenic processes of MBOCA.<br>

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