マウス線維肉腫の移植腫瘍系モデルにおける腫瘍増殖に対する銅キレート剤トリエンチンとX線照射の複合効果

DOI 日本農学文献記事索引 Web Site Web Site 被引用文献1件 参考文献70件
  • HAYASHI Masanobu
    Department of Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University
  • HIRAI Ryou
    Department of Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University
  • ISHIHARA Yuusuke
    Department of Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University
  • HORIGUCHI Noboru
    Department of Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University
  • ENDOH Daiji
    Department of Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University
  • OKUI Toyo
    Hokkaido Institute of Public Health

書誌事項

タイトル別名
  • Combined Effects of Treatment with Trientine, a Copper-Chelating Agent, and X-Irradiation on Tumor Growth in Transplantation Model of a Murine Fibrosarcoma
  • Laboratory animal science: Combined effects of treatment with trientine, a copper-chelating agent, and X-irradiation on tumor growth in transplantation model of a murine fibrosarcoma

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抄録

Combined effects of treatment with trientine, a copper-chelating agent, and X-irradiation on development of fibrosarcoma using a murine transplantation model in vivo and on cellular survival in vitro were examined. Copper contents in the tumors and serum of trientine-treated mice were significantly lower than those of untreated mice. The tumor volumes of mouse fibrosarcoma QRsp-11 cells increased more slowly in the trientine-treated and the X-irradiated mice than in the control mice from 10 to 24 days postinoculation. The extent of inhibition of tumor growth by X-irradiation at 3 Gy was similar to that obtained by treatment with trientine. A combination of trientine and X-irradiation at 3 Gy showed inhibitory effects on tumor growth similar to those obtained by X-irradiation at 6 Gy. The results showed that trientine and X-irradiation interacted additively in inhibition of tumor growth. When QRsp-11 cells and mouse and bovine endothelial cells were treated with trientine after X-irradiation, the surviving fractions of the cells with combined treatments were essentially consistent with the products of the surviving fractions of trientine-treated cells and those of X-irradiated cells. When the cells were pretreated with trientine and X-irradiated, the surviving fractions of the pretreated cells were lower than those of cells without treatment.<br>

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