Comparison of Antibody Titers in Rabbits Following Immunization with Inactivated Influenza Virus via Subarachnoidal or Subcutaneous Route

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  • SHIN Jae-Ho
    Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University National Institute of Toxicological Research, Korea Food and Drug Administration
  • SAKODA Yoshihiro
    Laboratory of Microbiology, Graduate School of Veterinary Medicine, Hokkaido University
  • KIM Jae Hoon
    Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Cheju National University
  • OCHIAI Kenji
    Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University
  • UMEMURA Takashi
    Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University

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  • Immunology: Comparison of antibody titers in rabbits following immunization with inactivated influenza virus via subarachnoidal or subcutaneous route

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Abstract

Rabbits were immunized with inactivated influenza virus via the subarachnoidal (SA) or subcutaneous (SC) route, and the antibody titers in cerebrospinal fluid (CSF) and serum were assayed. There were no nervous signs or morphological lesions related to SA immunization. In the SC group, the antibody titer was elevated in serum, but not elevated in CSF. In the SA group, the antibody titer was significantly elevated in serum and even in CSF, and their antibody titers were much greater than in the SC group. The present results suggest that intrathecal immunization is more effective than SC immunization at inducing a protective immune response against the transneural spread of viruses.<br>

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