Expression of Histamine H4 Receptor in Synovial Cells from Rheumatoid Arthritic Patients

DOI Web Site Web Site PubMed 被引用文献10件 参考文献30件
  • Ohki Emi
    Department of Geriatric Pharmacology & Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University
  • Suzuki Masahiko
    Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University
  • Aoe Tomohiko
    Department of Anesthesiology, Graduate School of Medicine, Chiba University
  • Ikawa Yoshiko
    Department of Geriatric Pharmacology & Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University
  • Negishi Etsuko
    Department of Geriatric Pharmacology & Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University
  • Ueno Koichi
    Department of Geriatric Pharmacology & Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University

この論文をさがす

抄録

The last of four histamine receptors (HRs), H4 receptor (H4R), was identified in the year 2000. Since that time, the H4R has been implicated in cellular mechanisms related to immune systems, inflammatory processes, and allergic reactions. We have previously reported the expression of H4R mRNA in rheumatoid arthritic (RA) synovial cell cultures by means of the RT-PCR method. The present study demonstrates the expression of H4R at the protein level in RA synovial cell cultures. We also identified that the receptor was expressed in two specific types of cell populations, fibroblast-like and macrophage-like cells from RA synovial tissues. In the culture system, the fifth generation of fibroblast-like synoviocytes showed as strong expression of H4R as in the primary culture. The results provide pragmatic evidence for H4R as a novel target in the development of pharmacotherapeutic agents for RA treatment. Furthermore, the culture system used here will be useful for future studies concerning basic molecular mechanisms underlying the pharmacology of H4R.

収録刊行物

被引用文献 (10)*注記

もっと見る

参考文献 (30)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ