Additive Mutagenic Effects of DNA Damages Induced by Multiple Mutagens at Virtually Non-mutagenic Dose Level of Each

• Ohta Toshihiro

  School of Life Sciences, Tokyo University of Pharmacy and Life Sciences

抄録

DNA damages provoked by the six mutagens (furylframide, MX, 4-nitroquinoline N-oxide, sodium azide, 1-nitropyrene, and captan) used in the present study have been known to subject to the nucleotide excision repair system. Therefore, they induced base-substitution mutations much more efficiently in Salmonella typhimurium TA100 (hisG46, rfa, uvrB/pKM101), a strain deficient in nucleotide excision repair, than in TA1975P (hisG46, rfa/pKM101). Doses below undetectable level in the reverse mutation assay were selected as those that were apparently mutagenic to the repair-deficient strain TA100 but not to the repair-proficient strain TA1975P in this study. Then, the six mutagens were mixed at virtually non-mutagenic dose level of each and a possible combined mutagenic effect was investigated. A significant and reproducible increase in the number of revertants in TA1975P was observed with combined mutagens. The results suggest that DNA adduct formation at virtually non-mutagenic dose level was additive, with the total amount reflecting the mutagenicity.<br>

収録刊行物

• Genes and Environment

  Genes and Environment 29 (4), 141-145, 2007

  日本環境変異原学会

キーワード

• threshold
• nucleotide excision repair
• combined mutagenicity
• additive effect
• <i>Salmonella typhimurium</i>

詳細情報

• CRID: 1390282680232849408
• NII論文ID: 110006474278
• NII書誌ID: AA1212552X
• DOI: 10.3123/jemsge.29.141
• ISSN: 18807062
• ISSN: 18807046
• NDL書誌ID: 9282477
• Web Site: http://id.ndl.go.jp/bib/9282477
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9282477
• Web Site: https://search.jamas.or.jp/link/ui/2008186215
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可