Preparation of Cyanoacrylate Nanoparticles Using Monosaccharides or Disaccharides

• Shirotake Shoichi

  Department of Pharmaco-Therapeutics, Graduate School of Medicine, Yokohama City University

• Tomita Yu'usuke

  Department of Pharmaco-Therapeutics, Graduate School of Medicine, Yokohama City University

• Yoshizaki Shinji

  Department of Pharmaco-Therapeutics, Graduate School of Medicine, Yokohama City University

• Okuda Kenji

  Department of Pharmaco-Therapeutics, Graduate School of Medicine, Yokohama City University

抄録

By using biomaterials, including monosaccharides and disaccharides, as polymeric stabilizing agents, the cyanoacrylate nanoparticles was prepared respectively, with particles diameter of approximately 200 nm or 300 nm. The new method was applied to load/encapsulate ampicillin (ABPC) and pDNA into nanoparticles. Loading efficiency of ABPC was increased compared to the existing method in which dextran is used as a stabilizer. The pDNA encapusulation rate was 68.7%, by using glucose.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 56 (1), 137-138, 2008

  公益社団法人 日本薬学会

キーワード

• cyanoacrylate
• nanoparticle
• saccharide
• encapsulation

詳細情報

• CRID: 1390001204168486144
• NII論文ID: 110006531710
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.56.137
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb/56/1/56_1_137/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可