Extracts of Momordica charantia Suppress Postprandial Hyperglycemia in Rats
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- UEBANSO Takashi
- Department of Clinical Nutrition, University of Tokushima Graduate School
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- ARAI Hidekazu
- Department of Clinical Nutrition, University of Tokushima Graduate School
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- TAKETANI Yutaka
- Department of Clinical Nutrition, University of Tokushima Graduate School
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- FUKAYA Makiko
- Department of Clinical Nutrition, University of Tokushima Graduate School
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- YAMAMOTO Hironori
- Department of Clinical Nutrition, University of Tokushima Graduate School
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- MIZUNO Akira
- Clinical Biology and Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
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- URYU Keisuke
- Bizen Chemical Co., Ltd.
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- HADA Takahiko
- Bizen Chemical Co., Ltd.
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- TAKEDA Eiji
- Department of Clinical Nutrition, University of Tokushima Graduate School
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Abstract
Momordica charantia (bitter melon) is commonly known as vegetable insulin, but the mechanisms underlying its hypoglycemic effect remain unclear. To address this issue, the effects of bitter melon extracts on postprandial glycemic responses have been investigated in rats. An aqueous extract (AE), methanol fraction (MF) and methanol insoluble fraction (MIF) were prepared from bitter melon. An oral sucrose tolerance test revealed that administration of AE, MF or MIF each significantly suppressed plasma glucose levels at 30 min as compared with the control. In addition, the plasma insulin level at 30 min was also significantly lower after MF administration than in the control in the oral sucrose tolerance test. By contrast, these effects of bitter melon extracts were not observed in the oral glucose tolerance test. In terms of mechanism, bitter melon extracts dose-dependently inhibited the sucrase activity of intestinal mucosa with IC50 values of 8.3, 3.7 and 12.0 mg/mL for AE, MF and MIF, respectively. The fraction with a molecular weight of less than 1,300 (LT 1,300) obtained from MF inhibited the sucrase activity most strongly in an uncompetitive manner with an IC50 value of 2.6 mg/mL. Taken together, these results demonstrated that bitter melon suppressed postprandial hyperglycemia by inhibition of α-glucosidase activity and that the most beneficial component is present in the LT 1,300 fraction obtained from MF.
Journal
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 53 (6), 482-488, 2007
Center for Academic Publications Japan
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Details 詳細情報について
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- CRID
- 1390001206323965312
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- NII Article ID
- 110006531867
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- NII Book ID
- AA00703822
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- COI
- 1:CAS:528:DC%2BD1cXosV2l
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- ISSN
- 18817742
- 03014800
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- NDL BIB ID
- 9308600
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed