がん化学療法を施行した外来患者における血清アルブミン濃度

DOI NDLデジタルコレクション 参考文献13件

書誌事項

タイトル別名
  • Serum Albumin Levels in Outpatients Receiving Anti-Cancer Chemotherapy

この論文をさがす

抄録

As hypoalbuminemia is a risk factor of severe hematological toxicity occurring in anticancer chemotherapy,we examined serum albumin levels in outpatients receiving several different chemotherapy regimens.The data of 4215 samples collected from 946 outpatients receiving anticancer chemotherapy were investigated.Mean (±SD) serum albumin was 3.8±0.4 g/dL with levels in the 2.0-2.9 g/dL,3.0-3.9 g/dL and 4.0-4.9 g/dL accounting for 2.5%,56.6% and 40.9% of the total number of samples,respectively.Serum albumin levels differed by disease and chemotherapy regimen.The mean albumin levels for each chemotherapy regimen were significantly directly correlated with hematocrit (rs=0.752,p<0.01),BMI (rs=0.581,p=0.02)and inversely correlated with age (rs=-0.578,p=0.02).The frequencies of hypoalbuminemia were higher in patients with gastric,pancreatic and esophageal cancer than in patients with breast and colorectal cancer (70.5-91.4% vs.20.3 -63.1%) since the former were older and had a lower BMI.These data suggests that the risk for a severe hematological toxicity and an alteration of pharmacokinetics in highly protein-bound anticancer agents increase in patients with gastric,pancreatic and esophageal cancer.

収録刊行物

  • 医療薬学

    医療薬学 33 (12), 1032-1036, 2007

    一般社団法人日本医療薬学会

参考文献 (13)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ