Local Release of Catecholamines From the Hearts of Patients With Tako-Tsubo-Like Left Ventricular Dysfunction
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- Kume Teruyoshi
- Department of Cardiology, Kawasaki Medical School
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- Kawamoto Takahiro
- Department of Cardiology, Kawasaki Medical School
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- Okura Hiroyuki
- Department of Cardiology, Kawasaki Medical School
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- Toyota Eiji
- Department of Cardiology, Kawasaki Medical School
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- Neishi Yoji
- Department of Cardiology, Kawasaki Medical School
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- Watanabe Nozomi
- Department of Cardiology, Kawasaki Medical School
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- Hayashida Akihiro
- Department of Cardiology, Kawasaki Medical School
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- Okahashi Noriko
- Department of Cardiology, Kawasaki Medical School
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- Yoshimura Yuki
- Department of Cardiology, Kawasaki Medical School
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- Saito Ken
- Department of Cardiology, Kawasaki Medical School
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- Nezuo Shintaro
- Department of Cardiology, Kawasaki Medical School
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- Yamada Ryotaro
- Department of Cardiology, Kawasaki Medical School
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- Yoshida Kiyoshi
- Department of Cardiology, Kawasaki Medical School
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Background The precise mechanism of tako-tsubo-like left ventricular (LV) dysfunction remains unclear, although recent studies have shown that activation of sympathetic tone might be involved. However, local release of catecholamines from cardiac sympathetic efferent neurons in patients with tako-tsubo-like LV dysfunction remains poorly understood. The purpose of this study was to investigate evidence of local release of catecholamines from the hearts of patients with tako-tsubo-like LV dysfunction. Methods and Results Five consecutive patients with tako-tsubo-like LV dysfunction were studied. After confirming LV apical ballooning and a normal coronary angiogram, sampling of blood for the measurement of plasma catecholamine levels was performed at the aortic root (Ao) and coronary sinus (CS). In all 5 cases, increased local release of norepinephrine from the heart was documented (597, 4,238, 2,121, 486, 371 pg/ml at the Ao; 836, 5,719, 3,386, 658, 472 pg/ml at the CS, respectively). Conclusions Increased cardiac catecholamines might cause the transient LV apical ballooning in patients with tako-tsubo-like LV dysfunction. (Circ J 2008; 72: 106 - 108)<br>
収録刊行物
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- Circulation Journal
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Circulation Journal 72 (1), 106-108, 2008
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390001205102891648
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- NII論文ID
- 110006533923
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- NII書誌ID
- AA11591968
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- COI
- 1:CAS:528:DC%2BD1cXhtlShs7s%3D
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- ISSN
- 13474820
- 13469843
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- PubMed
- 18159109
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可