Whole-Body Periodic Acceleration Enhances Brachial Endothelial Function

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Author(s)

    • MATSUMOTO Tetsuya
    • Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science
    • YAMANE Tetsunobu
    • Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science
    • TAKASHIMA Hiroyuki
    • Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science
    • NAKAE Ichiro
    • Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science
    • HORIE Minoru
    • Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

Abstract

<b>Background</b> Periodic acceleration in the direction of the spinal axis through repetitive movement increases the shear stress on the vascular endothelium. In the present study it was assessed whether whole-body periodic acceleration with a new device would enhance endothelial function in sedentary adult volunteers. <b>Methods and Results</b> Twenty-six sedentary subjects (44±3 years) were randomly assigned to remain sedentary or perform exercise training for 4 weeks, followed by crossover. Periodic acceleration was applied with a horizontal motion platform at 2-3 Hz and approximately ±2.2 m/s<sup>2</sup> for 45 min. Increases in the brachial artery diameter were examined at rest, during reactive hyperemia (flow-mediated dilatation: %FMD) and after sublingual administration of 0.3 mg nitroglycerin (%NTG) using high-resolution ultrasound. All subjects completed the study with no adverse side-effects. There were no significant changes in the resting heart rate or arterial pressure, body weight, or lipid profiles during the study. Although %FMD did not change during the non-training period with periodic acceleration, it significantly increased from 7.3±0.4% at baseline to 8.4±0.4% after the training period (p<0.05), while %NTG remained unchanged. <b>Conclusions</b> Whole-body periodic acceleration with a horizontal motion platform improved vascular endothelial function in sedentary adults. This device might offer an alternative to active exercise for patients whose medical condition limits physical activity. (<i>Circ J</i> 2008; <b>72:</b> 139 -143)<br>

Journal

  • Circulation Journal

    Circulation Journal 72(1), 139-143, 2007-12-20

    Japanese Circulation Society

References:  22

Cited by:  2

Codes

  • NII Article ID (NAID)
    110006533929
  • NII NACSIS-CAT ID (NCID)
    AA11591968
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13469843
  • Data Source
    CJP  CJPref  NII-ELS  J-STAGE 
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