A Plasmidic Class 1 Integron from Five Pseudomonas aeruginosa Clinical Strains Harbored aacA4 and Nonsense-mutated cmlA1 Gene Cassettes
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- Yan He
- College of Light Industry and Food Technology, South China University of Technology
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- Shi Lei
- College of Light Industry and Food Technology, South China University of Technology
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- Yamasaki Shinji
- College of Light Industry and Food Technology, South China University of Technology Osaka Prefecture University
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- Li Xinhui
- School of Biological Science and Bioengineering, South China University of Technology
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- Cao Yicheng
- School of Biological Science and Bioengineering, South China University of Technology
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- Li Lin
- College of Light Industry and Food Technology, South China University of Technology
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- Yang Liansheng
- College of Light Industry and Food Technology, South China University of Technology
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- Miyoshi Shin-ichi
- Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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抄録
Five strains of multidrug-resistant Pseudomonas aeruginosa (P. aeruginosa) were isolated from inpatients at a local hospital in China. The most frequent resistance was to cefoperazone, ciprofloxacin, ceftriaxone, cefotaxime, gentamicin, piperacillin, trimethoprim sulfamethoxazole, and tobramycin. These strains were found to contain the class 1 integron, in which the 2360-bp gene cassettes were flanked by 5'- and 3'-conserved segments. Sequence analysis revealed that the gene cassettes contained aacA4 and cmlA1 genes; however, the latter gene had a nonsense mutation resulting in the production of a truncated protein. To the best of our knowledge, this is the first report of a nonsense mutation in the cmlA1 gene. Moreover, the P. aeruginosa strains showed identical profiles in pulsed-field gel electrophoresis, suggesting that they were derived from the same clone. These results emphasize the importance of controlling the spread of multidrug-resistant pathogens in hospitals.
収録刊行物
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- JOURNAL OF HEALTH SCIENCE
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JOURNAL OF HEALTH SCIENCE 53 (6), 750-755, 2007
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679473758336
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- NII論文ID
- 110006545944
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- NII書誌ID
- AA11316464
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- ISSN
- 13475207
- 13449702
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- NDL書誌ID
- 9275606
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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