Compartmentalized Regulations of Ion Channels in the Heart

• Kurokawa Junko

  Department of Bio-Informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University

抄録

The rate and force of contraction of the heart are precisely controlled by compartmentalized regulation of cardiac ion channels which determine electrical activities. It is known that modulation of cardiac ion channels, which is caused by drug administration, sympathetic nervous system stimulation and gender difference, can increase risks of lethal arrhythmias in carriers of inherited disease mutations. These modulations are thought to also be involved in common cardiac arrhythmias. Because many signaling molecules are localized within single cells, an understanding of the molecular basis of compartmentalized regulation of cardiac channels is a key for understanding and treating the lethal arrhythmias. In this review, I will discuss molecular mechanisms of compartmentalized regulation of cardiac ion channels via drugs, cAMP and sex hormones.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 30 (12), 2231-2237, 2007

  公益社団法人 日本薬学会

キーワード

• ion channel
• heart
• compartmentalized regulation
• drug
• cAMP
• hormone

詳細情報

• CRID: 1390001204625434752
• NII論文ID: 110006546417
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.30.2231
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 9274138
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9274138
• Web Site: http://www.jstage.jst.go.jp/article/bpb/30/12/30_12_2231/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008132434
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可