Compartmentalized Regulations of Ion Channels in the Heart

• Kurokawa Junko

  Department of Bio-Informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University

Abstract

The rate and force of contraction of the heart are precisely controlled by compartmentalized regulation of cardiac ion channels which determine electrical activities. It is known that modulation of cardiac ion channels, which is caused by drug administration, sympathetic nervous system stimulation and gender difference, can increase risks of lethal arrhythmias in carriers of inherited disease mutations. These modulations are thought to also be involved in common cardiac arrhythmias. Because many signaling molecules are localized within single cells, an understanding of the molecular basis of compartmentalized regulation of cardiac channels is a key for understanding and treating the lethal arrhythmias. In this review, I will discuss molecular mechanisms of compartmentalized regulation of cardiac ion channels via drugs, cAMP and sex hormones.

Journal

• Biological and Pharmaceutical Bulletin

  Biological and Pharmaceutical Bulletin 30 (12), 2231-2237, 2007

  The Pharmaceutical Society of Japan

Keywords

• ion channel
• heart
• compartmentalized regulation
• drug
• cAMP
• hormone

Details

• CRID: 1390001204625434752
• NII Article ID: 110006546417
• NII Book ID: AA10885497
• DOI: 10.1248/bpb.30.2231
• ISSN: 13475215
• ISSN: 09186158
• NDL BIB ID: 9274138
• Web Site: http://id.ndl.go.jp/bib/9274138
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9274138
• Web Site: http://www.jstage.jst.go.jp/article/bpb/30/12/30_12_2231/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008132434
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed