炎症治療を目的としたNFκBデコイの細胞選択的ターゲティングシステムの開発  [in Japanese] Development of Cell-selective Targeting Systems of NFκB Decoy for Inflammation Therapy  [in Japanese]

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Author(s)

Abstract

  NFκB regulate several inflammatory related molecules and evoke immune and inflammatory response by several stimuli, therefore inhibition of NFκB activation would be a novel therapeutic strategy. To date, there are many conventional drugs including nonsteroldal or steroldal anti-inflammatory drugs or immune suppressors etc. were known to inhibit NFκB activation, however, several side effects were also reported. Recently, double stranded oligonucleotide including NFκB binding sequence, called NFκB decoy, was developed to prevent NFκB activation, which is powerful tool in a new class of anti-gene strategy for molecular therapy with low side effect. However, NFκB decoy is easily degraded by nuclease and rapidly excreted to urine, therefore it is necessary to develop carrier for NFκB decoy therapy. Here, we shall review delivery system for NFκB decoy and introduce our cell-selective delivery system for NFκB decoy using sugar decorated cationic liposomes.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 128(2), 209-218, 2008-02-01

    The Pharmaceutical Society of Japan

References:  60

Codes

  • NII Article ID (NAID)
    110006572174
  • NII NACSIS-CAT ID (NCID)
    AN00284903
  • Text Lang
    JPN
  • Article Type
    REV
  • ISSN
    00316903
  • NDL Article ID
    9369454
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z19-411
  • Data Source
    CJP  NDL  NII-ELS  J-STAGE 
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