Current Topics in DNA Double-Strand Break Repair

Author(s)

Abstract

DNA double strand break (DSB) is one of the most critical types of damage which is induced by ionizing radiation. In this review, we summarize current progress in investigations on the function of DSB repair-related proteins. We focused on recent findings in the analysis of the function of proteins such as 53BP1, histone H2AX, Mus81-Eme1, Fanc complex, and UBC13, which are found to be related to homologous recombination repair or to non-homologous end joining. In addition to the function of these proteins in DSB repair, the biological function of nuclear foci formation following DSB induction is discussed.

Journal

  • Journal of Radiation Research

    Journal of Radiation Research 49(2), 93-103, 2008-03-15

    Journal of Radiation Research Editorial Committee

References:  73

Cited by:  5

Codes

  • NII Article ID (NAID)
    110006633651
  • NII NACSIS-CAT ID (NCID)
    AA00705792
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    04493060
  • NDL Article ID
    9421067
  • NDL Source Classification
    ZS45(科学技術--医学--放射線医学)
  • NDL Call No.
    Z53-P232
  • Data Source
    CJP  CJPref  NDL  NII-ELS  IR  J-STAGE  NDL-Digital 
Page Top