Effect of low-dose total-body irradiation on transplantabilily of tumor cells in syngeneic mice

• ITO Masato

  Department of Radiology, Nagoya City University Graduate School of Medical Sciences

• SHIBAMOTO Yuta

  Department of Radiology, Nagoya City University Graduate School of Medical Sciences

• AYAKAWA Shiho

  Department of Radiology, Nagoya City University Graduate School of Medical Sciences

• TOMITA Natsuo

  Department of Radiology, Nagoya City University Graduate School of Medical Sciences

• SUGIE Chikao

  Department of Radiology, Nagoya City University Graduate School of Medical Sciences

• OGINO Hiroyuki

  Department of Radiology, Nagoya City University Graduate School of Medical Sciences

書誌事項

タイトル別名

• Effect of Low-Dose Total-Body Irradiation on Transplantability of Tumor Cells in Syngeneic Mice

抄録

The effect of pretreatment with various low doses of total-body irradiation (TBI) on tumor cell transplantability in syngeneic mice was investigated. Two cell lines, EMT6 and SCCVII, and two strains of mice, were used. First, Balb/c mice were sham-irradiated or irradiated at 200 mGy, and 6-48 h later, 1000 EMT6 cells were inoculated in the hind legs. Based on the results, 0-1500 mGy of TBI was given 6 h before inoculation of 100 or 1000 cells in the subsequent experiments. All mice were observed for 50 days after transplantation. Tumors were judged as grown when the volume of palpable nodules exceeded 200 mm³. Tumor transplantability rate was significantly higher in the groups irradiated at 1500 mGy than in the sham-irradiated groups in both Balb/c and C3H/He mice. There were no differences in transplantability rates between the control group and the groups irradiated at various doses of 50-500 mGy. However, the mean time to tumor appearance was significantly elongated in Balb/c mice receiving TBI at 200 mGy and inoculated with 100 or 1000 EMT6 cells 6 h later. This phenomenon was also observed in Balb/c mice receiving 100 mGy TBI and inoculated with 1000 EMT6 cells. The present study might suggest that low-dose TBI to mice may delay tumor growth under certain conditions.

収録刊行物

• Journal of Radiation Research

  Journal of Radiation Research 49 (2), 197-201, 2008

  Journal of Radiation Research 編集委員会

キーワード

• Low-dose radiation
• Total-body irradiation
• Tumor transplantability

詳細情報

• CRID: 1390001205217562624
• NII論文ID: 110006633662
• NII書誌ID: AA00705792
• DOI: 10.1269/jrr.07094
• ISSN: 13499157
• ISSN: 04493060
• NDL書誌ID: 9421148
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9421148
• Web Site: http://academic.oup.com/jrr/article-pdf/49/2/197/2758134/jrr-49-197.pdf
• Web Site: http://dl.ndl.go.jp/info:ndljp/pid/10919028
• Web Site: https://search.jamas.or.jp/link/ui/2008231283
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • NDL-Digital
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可