Ureaplasma urealyticum and Mycoplasma hominis Presence in Umbilical Cord is Associated with Pathogenesis of Funisitis

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Author(s)

    • Egawa Tsuyoshi
    • Department of Pediatrics, Kobe University Graduate School of Medicine
    • Morioka Ichiro
    • Department of Pediatrics, Kobe University Graduate School of Medicine
    • Yokoyama Naoki
    • Department of Pediatrics, Kobe University Graduate School of Medicine
    • Nakao Hideto
    • Department of Neonatology, Kobe Children's Hospital Perinatal Center
    • Ohashi Masanobu
    • Department of Obstetrics, Kobe Children's Hospital Perinatal Center
    • Matsuo Masafumi
    • Department of Pediatrics, Kobe University Graduate School of Medicine

Abstract

Ureaplasma urealyticum (U. urealyticum) and Mycoplasma hominis (M. hominis) areknown to cause an intrauterine infection for preterm deliveries, but it is not knownwhether they are actually pathogenically involved in the development of funisitis,chorioamnionitis (CAM), and chronic lung disease (CLD) in preterm infants. Ourpurpose was to identify U. urealyticum and M. hominis in the umbilical cord, placenta,and tracheal aspirate (TA) or gastric fluid (GF) of preterm infants, and to clarifywhether they contribute to funisitis, CAM, and CLD. Of 128 preterm infants, 86umbilical cords, 83 placentas, and 84 TA or GF samples obtained postnatally frompreterm infants were examined. U. urealyticum and M. hominis were detected bypolymerase chain reaction and prospectively analyzed to determine whether thepresence of U. urealyticum or M. hominis can lead to the development of funisitis, CAM,and CLD. U. urealyticum or M. hominis was isolated in nine (10.5%) of the umbilicalcords, five (6.0%) of the placentas, and fifteen (17.9%) of the TA or GF samples.Funisitis was identified in all umbilical cords with U. urealyticum or M. hominis, but inonly 13% of the umbilical cords without U. urealyticum and M. hominis (p < 0.001).Placentas and TA or GF with or without U. urealyticum and M. hominis did not showsignificant differences with regard to the development of CAM or CLD. Our resultssuggest that U. urealyticum and M. hominis presence is associated with the pathogenesisof funisitis, but not of CAM or CLD.

Journal

  • The Kobe journal of the medical sciences

    The Kobe journal of the medical sciences 53(5), 241-249, 2007-01

    Kobe University

Codes

  • NII Article ID (NAID)
    110006646847
  • NII NACSIS-CAT ID (NCID)
    AA00711740
  • Text Lang
    ENG
  • Article Type
    departmental bulletin paper
  • ISSN
    0023-2513
  • Data Source
    NII-ELS  IR 
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