Pharmacokinetics of Injected Mecobalamin (Methylcobalamin) in Healthy Adults : Intravenous and Intramuscular Routes
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- OGAWA Tadasu
- Eizai Co. Ltd.
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- TOMONO Yoshiro
- Eizai Co. Ltd.
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- MORISHITA Nobumichi
- Eizai Co. Ltd.
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- SHISHIDO Ryo
- Housen Clinic
Bibliographic Information
- Other Title
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- 健常成人における非経口的メコバラミン(メチルコバラミン)投与時の生体内動態 : 静注及び筋注による検討
- ケンジョウ セイジン ニ オケル ヒ ケイコウテキ メコバラミン メチルコバラ
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Abstract
Mecobalamin (CH_3-B_<12>), 500μg, was administered to 12 healthy adult volunteers by intravenous (IV) and intramuscular (IM)) injection by the cross-over method, and then the change in total B_<12> concentration in the serum was compared. The maximum serum B_<12> concentration (ΔC_<max>) and the area under the time curve (ΔAUC) of the serum total B_<12> concentration were both higher following IV injection than after IM injection: ca. 3.8-fold and 1.8-fold, respectively. These differences between the two administration routes were statistically significant. However, the saturated-bound rate, which reflects the amount of transcobalamin-II, was 90% or higher during the 1-12 hour period after administration by both routes. The subsequent pattern of decrease in this rate was similar for both routes. In addition, CH_3-B_<12> was administered to 6 healthy adult volunteers by IV injection of 500μg once a day for 10days. The minimum serum total B_<12> concentration (ΔC_<min>) increased gradually during the administration period and was about 1.7 times higher on 3 days after administration than on the first day. There-after, the concentration became constant. Moreover, the total B_<12> urinary excretion and the saturated-bound rate were increased during the 24-48 hour period after completion of the repeated administration. These findings indicate that, in repeated administration, B_<12> is accumulated in the liver and then gradually released into the blood.
Journal
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- VITAMINS
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VITAMINS 63 (3), 123-131, 1989
THE VITAMIN SOCIETY OF JAPAN
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Keywords
Details 詳細情報について
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- CRID
- 1390001205834413696
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- NII Article ID
- 110006663649
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- NII Book ID
- AN00207833
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- ISSN
- 2424080X
- 0006386X
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- NDL BIB ID
- 3239776
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed