Administration of Perilla Oil Coated with Calshell Increases Glucagon-Like Peptide Secretion

• Adachi Tetsuya

  Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University

• Yanaka Hiroyuki

  KITII Co., Ltd.

• Kanai Hitoshi

  KITII Co., Ltd.

• Nozaki Mayu

  KITII Co., Ltd.

• Takahara Yoshiyuki

  Pharma Frontier Co., Ltd.

• Tsuda Mariko

  Laboratory of Metabolism, Graduate School of Human and Environmental Studies, Kyoto University

• Jonouchi Tatsuya

  Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University

• Tsuda Kinsuke

  Laboratory of Metabolism, Graduate School of Human and Environmental Studies, Kyoto University

• Hirasawa Akira

  Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University

• Tsujimoto Gozoh

  Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University

抄録

Recently, we found that unsaturated long-chain fatty acids (such as α-linolenic acid) promote the secretion of glucagon-like peptide-1 (GLP-1) via G protein-coupled receptor GPR120, which is expressed predominantly in the colon. In order to ensure that the triglycerides or free fatty acids, such as α-linolenic acid, reach the distal intestinal tract effectively, we developed a Calshell technique. Following single treatment of Calshell perilla oil powder, the GLP-1 secretion level was significantly higher than following vehicle treatment, 120 min after treatment. Next, we examined the effects of long-term Calshell perilla oil powder treatment on GLP-1 secretion. Plasma GLP-1 level of Calshell perilla oil powder treatment was significantly higher than of vehicle treatment for 1, 14, 28 and 56 d. We thereby demonstrated for the first time the utility of Calshell oil powder treatment for effective and sustainable GLP-1 secretion. The Calshell technique is apparently useful as a drug delivery system, since Calshell unsaturated oil powder is protected from gastric acid, reaches enteroendocrine cells in the gastrointestinal tract, and then induces effective incretin secretion.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 31 (5), 1021-1023, 2008

  公益社団法人 日本薬学会

キーワード

• Calshell
• perilla oil
• glucagon-like peptide-1
• insulin
• mouse

詳細情報

• CRID: 1390001204626047744
• NII論文ID: 110006663973
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.31.1021
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 9474346
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9474346
• Web Site: http://www.jstage.jst.go.jp/article/bpb/31/5/31_5_1021/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008295441
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
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