Preparation, characterization and in vitro anticancer activity of platinum(2) complexes with N-cyclohexyl-1,3-propanediamine as the carrier

• Liu Weiping

  Platinum-Based Drug Lab, Kunming Institute of Precious Metals

• Qing Chen

  Kunming Medical College

• Chen Xizhu

  Platinum-Based Drug Lab, Kunming Institute of Precious Metals

• Ye Qingsong

  Platinum-Based Drug Lab, Kunming Institute of Precious Metals

• Yu Yao

  Platinum-Based Drug Lab, Kunming Institute of Precious Metals

• Hou Shuqian

  Platinum-Based Drug Lab, Kunming Institute of Precious Metals

書誌事項

タイトル別名

• Preparation, Characterization and in Vitro Anticancer Activity of Platinum(II) Complexes with N-Cyclohexyl-1,3-propanediamine as the Carrier

抄録

New JM118 (active form of satraplatin) analogues with N-cyclohexyl-1,3-propanediamine (N-chpda) as the carrier, cis-[Pt(N-chpda)X₂] (X₂=2Cl⁻ (1), oxalate (2), malonate (3), 1,1-cyclobutanedicarboxylate (CBDCA) (3), and 3-hydroxy-1,1-cyclobutanedicarboxylate(HO-CBDCA) (4)), have been synthesized and characterized by elemental analysis and spectroscopic data along with X-ray crystal structure for a representative compound cis-[Pt(N-chpda)Cl₂].The complexes have also been evaluated for their in vitro anticancer activity. All these analytical data are in good agreement with the structures of the desired compounds. The Pt(II) is in a square planar environment and is coordinated by a chelating N-chpda ligand and 2Cl⁻ in cis position, and there are two crystallographically independent cis-[Pt(N-chpda)Cl₂] molecules linked together by intermolecular N–H···Cl hydrogen bonds. Compounds 1 and 2 are very active against human lung cancer cell line (AGZY) and human lymphocytic leukemia cell line (Raji), and are much more active than carboplatin. Platinum(II) complexes with N-cyclohexyl-1,3-propanediamine is an alternative choice for mixed ammine/aminoplatinum anticancer drugs.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 56 (5), 659-662, 2008

  公益社団法人 日本薬学会

キーワード

• analogue
• JM118
• synthesis
• structure
• anticancer activity

詳細情報

• CRID: 1390282679147820544
• NII論文ID: 110006663987
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.56.659
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 9473621
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9473621
• Web Site: http://www.jstage.jst.go.jp/article/cpb/56/5/56_5_659/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008265851
• 本文言語コード: en
• データソース種別:
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• 抄録ライセンスフラグ: 使用不可