28 附子中の強心成分,Higenamineの分離及びその構造について

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  • 28 STUDY ON CARDIAC PRINCIPLE OF ACONITE ROOT

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As a cardiac principle of aconite root, Yokonoside had been reported by us in previous meeting, but synthesized Yokonoside did not have any biological activities. Then, separating procedure had been reinvestigated to obtain the true cardiac principle. In order to remove the inactive glycoside, the fractn. III was subjected to counter current distribution of n-buthanol-0.1N-HCl solvent system. And a crystalline matter (mp.260°), was obtained as colorless plate from the active fractn. IV as HCl-salt. The principle stimulates flog's heart even in ten billionth dilution, thus it was designated as Higenamine. Higenamine was identified as dl-demethyl coclaurine [V] from the spectral data and in comparison with synthesized authentic sample.

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