2 ガガイモ科及びナス科植物のステロイドとその細胞分化誘導活性(口頭発表の部)

• 黒柳 正典

  静岡県大・薬

• 梅原 薫

  静岡県大・薬

• 柴田 和利

  静岡県大・薬

• 砂山 玲子

  静岡県大・薬

• 遠藤 深春

  静岡県大・薬

• 佐藤 裕子

  静岡県大・薬

• 白須 直美

  静岡県大・薬

• 上野 明

  静岡県大・薬

書誌事項

タイトル別名

• 2 STEROIDS FROM ASCLEPIADACEOUS AND SOLANACEOUS PLANTS AND THEIR CELL DIFFERENTIATION INDUCING ACTIVITY

抄録

Although much attention has been given to cell differentiation inducers as new types of anti-tumore agent, only a few studies has been reported on differentiation inducers from plant sorces. Therefore, we have searched for naturally occouring substances which induce differnciation of leukemia cells. From Condurango Cortex (Marsdenia condurango) (Asclepidaceae) and Periplocae Cortex (Periploca sepium B.) (Asclepidaceae), many kids of pregnan derivatives and some cardenolides. From withania (Withania somnifera) (Solanaceae) (using Indian market withania and withania cultivated at the medicinal plant garden of this university), more than thirty kinds of withanolides were isolated. From Physalis alkekengi (Solanaceae), physalin and neophysalin derivatives were isolated. Structural elucidation of these 60 kinds of steroid derivatives were carried out by means of spectral methods, especially using NMR spectroscopy including H-H COSY, H-C COSY, HMBC, NOE technics. These steroidal derivatives were tested on cell differentiatio inducing activity against mouse myeloid leukemia (M1) cells. Many kinds steroid derivatives showed the activity. Of these active compounds, some kinds of withanolids, 27, 33, 34 and 35 having 4β-hydroxy-5β,6β-epoxy-2-en-1-one structure of AB ring, showed potent differentiation inducing activity.

収録刊行物

• 天然有機化合物討論会講演要旨集

  天然有機化合物討論会講演要旨集 36 (0), 9-16, 1994

  天然有機化合物討論会実行委員会

詳細情報

• CRID: 1390001206077704832
• NII論文ID: 110006679267
• DOI: 10.24496/tennenyuki.36.0_9
• ISSN: 24331856
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可