A Novel Mutation Associated With Jervell and Lange-Nielsen Syndrome in a Japanese Family

DOI Web Site 参考文献67件
  • Ohno Seiko
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine
  • Kubota Tomoyuki
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine
  • Yoshida Hidetada
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine
  • Tsuji Keiko
    Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science
  • Makiyama Takeru
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine
  • Yamada Satsuki
    Department of Internal Medicine, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba
  • Kuga Keisuke
    Department of Internal Medicine, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba
  • Yamaguchi Iwao
    Department of Internal Medicine, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba
  • Kita Toru
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine
  • Horie Minoru
    Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

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Background The Jervell and Lange-Nielsen (JLN) syndrome is a variant of long QT syndromes (LQTS) and is associated with congenital deafness. The syndrome is caused by homozygous or compound heterozygous mutations in genes KCNQ1 and KCNE1, which are responsible for encoding the delayed rectifier repolarizing current, IKs. Methods and Results A novel and homozygous KCNQ1 mutation in a 23-year-old deaf woman with a prolonged QT interval and recurrent syncope in a Japanese family was identified. Genetic analyses revealed that the proband harbored a KCNQ1 missense mutation (W248F) located in the intracellular S4-S5 linker on both alleles. The same mutation was identified in both maternal and paternal families in a heterozygous manner. However, the family members of both sides had no clinical evidence of LQTS or hearing defects. Functional assays using a heterologous expression system revealed that W248F KCNQ1 plus KCNE1 channels reconstitute hardly measurable IKs currents. In contrast, heterozygous wild-type/W248F KCNQ1 plus KCNE1 channels displayed biophysical properties similar to those of the wild-type KCNQ1 plus KCNE1 channels with a weak dominant-negative effect. Conclusion In this study, we present a family with JLN syndrome. The electrophysiological properties of the mutant IKs channels explain the pathophysiology underlying JLNS. (Circ J 2008; 72: 687 - 693)<br>

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  • Circulation Journal

    Circulation Journal 72 (5), 687-693, 2008

    一般社団法人 日本循環器学会

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