Association Between Low Birth Weight and Elevated White Blood Cell Count in Adulthood Within a Japanese Population

• Wada Keiko

  Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine

• Tamakoshi Koji

  Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine

• Ouyang Pei

  Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine

• Otsuka Rei

  Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine

• Mitsuhashi Hirotsugu

  Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine Department of Cardiology, Nagoya University Graduate School of Medicine

• Takefuji Seiko

  Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine Department of Endocrinology, Nagoya University Graduate School of Medicine

• Matsushita Kunihiro

  Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine Department of Cardiology, Nagoya University Graduate School of Medicine

• Sugiura Kaichiro

  Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine Department of Cardiology, Nagoya University Graduate School of Medicine

• Hotta Yo

  Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine Department of Endocrinology, Nagoya University Graduate School of Medicine

• Toyoshima Hideaki

  Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine

• Yatsuya Hiroshi

  Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine

抄録

Background Epidemiological studies have demonstrated the association between low birth weight and increased adulthood risk for cardiovascular and metabolic diseases. However, the precise mechanism underlying the association remains poorly understood. We investigated the association between birth weight and adult white blood cell (WBC) count in a Japanese population. Methods and Results The subjects were 779 men and 209 women aged 35-64 years. The mean WBC count was 5,283 /μl (SD: 1,326). Birth weight was divided to 6 categories: <2,500, 2,500-<2,800, 2,800-<3,000, 3,000-<3,200, 3,200-<3,500, and >3,500 g. Estimated WBC counts were 5,729, 5,341, 5,301, 5,212, 5,013 and 5,372 for the subjects with birth weights of the above respective categories (p=0.015, trend p=0.016) by one-way analysis of covariance after adjustments for sex, age, height, body mass index (BMI), lifestyles, and chronic diseases. This association was pronounced among the subjects with a BMI <25.0 kg/m² rather than those with a higher BMI. Conclusions These findings support the idea that part of the association of low birth weight with elevated risk for vascular and metabolic diseases in later life could be mediated by an inflammatory pathway. (Circ J 2008; 72: 757 - 763)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 72 (5), 757-763, 2008

  一般社団法人 日本循環器学会

キーワード

• Cardiovascular diseases
• Inflammation
• Intrauterine environment
• Risk factors

詳細情報

• CRID: 1390282680079158144
• NII論文ID: 110006680555
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.72.757
• COI: 1:STN:280:DC%2BD1c3nvVOnuw%3D%3D
• ISSN: 13474820
• ISSN: 13469843
• Web Site: http://www.jstage.jst.go.jp/article/circj/72/5/72_5_757/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008234254
• 本文言語コード: en
• データソース種別:
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  • Crossref
  • CiNii Articles
  • KAKEN
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