Effects of Metabolic Risk Factors on Production of Plasminogen Activator Inhibitor-1 and Adiponectin by Adipocytes
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- Sakamoto Kenji
- Division of Cardiology, Health Insurance Yatsushiro General Hospital
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- Sakamoto Tomohiro
- Division of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center
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- Ogawa Hisao
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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Background Type 1 plasminogen activator inhibitor (PAI-1) and adiponectin are produced by adipocytes and are important in the progression of coronary artery disease (CAD). Methods and Results Different concentrations of glucose, insulin and 1% triglycerides were used to assay PAI-1 and adiponectin production from cultured adipocytes. Triglycerides induced the highest PAI-1 production with 16.5 mmol/L glucose and 50 nmol/L insulin. In contrast, glucose and insulin decreased adiponectin production in a dose-dependent manner irrespective of triglycerides. Conclusion The metabolic syndrome risk factors alter PAI-1 and adiponectin production by adipocytes, in the presence or absence of triglycerides, which might play a role in the development of CAD. (Circ J 2008; 72: 844 - 846)<br>
収録刊行物
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- Circulation Journal
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Circulation Journal 72 (5), 844-846, 2008
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390001205102460416
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- NII論文ID
- 110006680568
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- NII書誌ID
- AA11591968
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- COI
- 1:STN:280:DC%2BD1c3nvVOlsA%3D%3D
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- ISSN
- 13474820
- 13469843
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可