88(P-45) Pamamycin-607の合成研究(ポスター発表の部)

• 古屋 幸人

  東北大院農・応生科

• 清田 洋正

  東北大院農・応生科

• 桑原 重文

  東北大院農・応生科

書誌事項

タイトル別名

• 88(P-45) Synthetic Studies of Pamamycin-607

抄録

Pamamycins are a series of antibiotic macrodiolides isolated from various Streptomyces species. Among them, pamamycin-607 (1) exhibited aerial mycelium-inducing activity for an aerial mycelium-negative mutant strain and showed antibiotic activity against Gram positive bacteria and fungi. Several synthetic studies including the northern and the southern fragment have been reported to date. In our preliminary communication, we reported the synthesis of the southern fragment (2). In addition, we have also achieved the synthesis of the eastern fragment. Herein we describe the synthetic pathways of these two fragments including experimental details. Synthesis of the southern C1'-C11' and eastern C8-C18 fragments of pamamycin-607, an aerial mycelium-inducing substance of Streptomyces alboniger, was achieved. The southern fragment was synthesized by using Evans aldol reaction and cis-selective iodoetherification as the key steps in 9.6% overall yield (7 steps). The eastern fragment was also constructed via Julia coupling reaction and cis-selective iodoetherification in 3.0% overall yield (8 steps from the known epoxide).

収録刊行物

• 天然有機化合物討論会講演要旨集

  天然有機化合物討論会講演要旨集 43 (0), 521-526, 2001

  天然有機化合物討論会実行委員会

詳細情報

• CRID: 1390001206079243520
• NII論文ID: 110006682133
• DOI: 10.24496/tennenyuki.43.0_521
• ISSN: 24331856
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可