Morphology and Surface States of Colloidal Probucol Nanoparticles Evaluated by Atomic Force Microscopy

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Abstract

Morphology and surface states of colloidal probucol nanoparticles after dispersion of probucol/polyvinylpyrrolidone (PVP)/sodium dodecyl sulphate (SDS) ternary ground mixture into water were investigated by atomic force microscopy (AFM). The observed particles had core-shell structure, <i>i.e.</i> drug nanocrystals were covered with PVP and SDS complex. The AFM phase image and the force curve analyses indicated that probucol nanoparticles with PVP K17 showed layer structure, compared to those with PVPK12. The structural difference was explainable in terms of the molecular states of PVP-SDS complex on the particle surface. These findings support not only the mechanism of drug nanoparticle formation but also the <i>in vivo</i> absorption results with the almost same particle size of <i>ca.</i> 40 nm.

Journal

  • Chemical and Pharmaceutical Bulletin

    Chemical and Pharmaceutical Bulletin 56(6), 878-880, 2008-06-01

    The Pharmaceutical Society of Japan

References:  16

Cited by:  1

Codes

  • NII Article ID (NAID)
    110006684296
  • NII NACSIS-CAT ID (NCID)
    AA00602100
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00092363
  • NDL Article ID
    9509078
  • NDL Source Classification
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No.
    Z53-D167
  • Data Source
    CJP  CJPref  NDL  NII-ELS  J-STAGE 
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