ニューロイメージングを中間表現型としたADHDへのアプローチ

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  • A review of neuroimaging studies of ADHD: an endophenotype approach
  • ニューロ イメージング オ チュウカン ヒョウゲンガタ トシタ ADHD エノ アプローチ

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論文(Article)

Abstract : Attention-deficit/hyper activity disorder (ADHD) is a behavioral-developmental disorder that is characterized by symptoms such as increased impulsivity (weakness for inhibitory control), inattention and hyperactivity. Recently, a large number of studies have investigated the underlying neural substrates of ADHD utilizing molecular genetics, samples of twins, and cognitive neuroscience neuroimaging techniques. These studies suggest that abnormalities of neurotransmitters and dysfunctions of the fronto-striatal circuitry system may be primary causes of ADHD. In this paper, we review cognitive neuroscience literature of ADHD using functional and structural magnetic resonance imaging (MRI). This article describes an endophenotype of ADHD from a neuroimaging perspective and highlights the need for work research that integrates both neuroimaging and genetic research techniques in order to elucidate the neural substrates underling ADHD.

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