甘味感受性に影響する温度依存的なTrpm5の働き(セミナー「生体の温度・水分センサーの機能と構造」)

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  • The Role of Trpm5 in Thermal Sensitivity of Sweet Taste(Papers presented at the Seminar, "Function and structure of thermo/moisture sensors in biosystem")
  • 甘味感受性に影響する温度依存的なTrpm5の働き
  • カンミ カンジュセイ ニ エイキョウスル オンド イソンテキナ Trpm5 ノ ハタラキ

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Trpm5, calcium-activated cation channel of the TRP superfamily, is highly expressed in taste buds of the tongue, where it has a key role in the perception of sweet, umami and bitter tastes. Activation of Trpm5 occurs downstream of the activation of G-protein-coupled taste receptors and is proposed to generate a depolarizing potential in the taste receptor cells. Factors that modulate Trpm5 activity are therefore expected to influence taste. Here we show that Trpm5 is a highly temperature-sensitive, heat-activated channel: inward Trpm5 currents increase steeply at temperatures between 15 and 35 degrees C. Heat activation is due to a temperature-dependent shift of the activation curve, in analogy to other thermosensitive TRP channels. Moreover, we show that increasing temperature between 15 and 35 degrees C markedly enhances the gustatory nerve response to sweet compounds in wild-type but not in Trpm5 knockout mice. The strong temperature sensitivity of Trpm5 may underlie known effects of temperature on perceived taste in humans, including enhanced sweetness perception at high temperatures and 'thermal taste`, the phenomenon whereby heating or cooling of the tongue evoke sensations of taste in the absence of tastants.

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