Small Dense LDL-Cholesterol Relative to LDL-Cholesterol is a Strong Independent Determinant of Hypoadiponectinemia in Metabolic Syndrome

• Satoh Noriko

  Division of Metabolic Research, Clinical Research Institute for Endocrine and Metabolic Diseases, National Hospital Organization, Kyoto Medical Center

• Wada Hiromichi

  Division of Translational Research, Clinical Research Institute for Endocrine and Metabolic Diseases, National Hospital Organization, Kyoto Medical Center

• Ono Koh

  Division of Translational Research, Clinical Research Institute for Endocrine and Metabolic Diseases, National Hospital Organization, Kyoto Medical Center

• Yamakage Hajime

  Division of Metabolic Research, Clinical Research Institute for Endocrine and Metabolic Diseases, National Hospital Organization, Kyoto Medical Center

• Yamada Kazunori

  Diabetes Center, National Hospital Organization, Kyoto Medical Center

• Nakano Tameo

  Department of Cardiovascular Medicine, National Hospital Organization, Kyoto Medical Center

• Hattori Masakazu

  Division of Metabolic Research, Clinical Research Institute for Endocrine and Metabolic Diseases, National Hospital Organization, Kyoto Medical Center

• Shimatsu Akira

  Division of Metabolic Research, Clinical Research Institute for Endocrine and Metabolic Diseases, National Hospital Organization, Kyoto Medical Center

• Kuzuya Hideshi

  Diabetes Center, National Hospital Organization, Kyoto Medical Center

• Hasegawa Koji

  Division of Translational Research, Clinical Research Institute for Endocrine and Metabolic Diseases, National Hospital Organization, Kyoto Medical Center

Abstract

Background Small dense low-density lipoprotein (sd-LDL) is an atherogenic lipoprotein closely associated with an increased risk of cardiovascular diseases. However, a precise analysis of the actual amount of sd-LDL-cholesterol (sd-LDL-C) in patients with metabolic syndrome (MS) has not been performed. Methods and Results Among 214 patients enrolled in the present study, 101 patients (47%) met the Japanese MS criteria. The serum levels of sd-LDL-C determined with a dual detection HPLC system were higher in MS than non-MS patients, while total cholesterol and low-density lipoprotein-cholesterol (LDL-C) were similar between MS and non-MS patients. Compared with the sd-LDL-C and LDL-C level, the ratio sd-LDL-C/LDL-C was more closely correlated with various parameters associated with MS. A multivariate regression analysis revealed that the ratio sd-LDL-C/LDL-C is the strongest independent determinant of hypoadiponectinemia. Furthermore, weight reduction therapy through diet and exercise rapidly decreased LDL-C but slowly decreased sd-LDL-C. At 12 months after the therapy, weight reduction led to a significant decrease in the ratio sd-LDL-C/LDL-C in tandem with increasing adiponectin levels. Conclusions These findings demonstrate that the ratio sd-LDL-C/LDL-C is tightly connected with hypoadiponectinemia and provides a useful clinical indicator for MS. The results also suggest that the elevation of this ratio can be modulated by long-term lifestyle changes. (Circ J 2008; 72: 932 - 939)<br>

Journal

• Circulation Journal

  Circulation Journal 72 (6), 932-939, 2008

  The Japanese Circulation Society

Keywords

• Lifestyle
• Lipoproteins
• Metabolic syndrome
• Obesity
• Risk factors

Details

• CRID: 1390001205102591872
• NII Article ID: 110006783830
• NII Book ID: AA11591968
• DOI: 10.1253/circj.72.932
• ISSN: 13474820
• ISSN: 13469843
• Web Site: http://www.jstage.jst.go.jp/article/circj/72/6/72_6_932/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008309974
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed