Quantification of Regional Myocardial Blood Flow Using First-Pass Multidetector-Row Computed Tomography and Adenosine Triphosphate in Coronary Artery Disease

• Kido Teruhito

  Department of Diagnostic and Therapeutic Radiology, Ehime University Graduate School of Medicine

• Kurata Akira

  Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine

• Higashino Hiroshi

  Department of Diagnostic and Therapeutic Radiology, Ehime University Graduate School of Medicine

• Inoue Yuma

  Department of Diagnostic and Therapeutic Radiology, Ehime University Graduate School of Medicine

• Kanza Rene Epunza

  Department of Diagnostic and Therapeutic Radiology, Ehime University Graduate School of Medicine

• Okayama Hideki

  Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine

• Higaki Jitsuo

  Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine

• Murase Kenya

  Medical Physics and Engineering, Osaka University Graduate School of Medicine

• Mochizuki Teruhito

  Department of Diagnostic and Therapeutic Radiology, Ehime University Graduate School of Medicine

Abstract

Background The feasibility of using cardiac multidetector-row computed tomography (MDCT) technology in the quantitative assessment of myocardial blood flow (MBF) using the adenosine triphosphate (ATP) load technique was investigated in the present study. Methods and Results The study group comprised 14 patients (11 men, 3 women, age range 52-79 years, mean age 69.2 years) who underwent cardiac cine MDCT using the ATP-load technique. MBF was estimated from the slope of the linear regression equation with Patlak plots analysis. The overall average MBF was 1.83±0.62 ml · g^-1 · min^-1. Mean MBF in territories with stenosis on coronary angiography was 1.19±0.36 ml · g^-1 · min^-1 and 2.06±0.54 ml · g^-1 · min^-1 (p<0.01) in territories without stenosis. The average MBF in territories with moderate to severe ischemia on myocardial perfusion scintigraphy was 1.32±0.14 ml ·g^-1 · min^-1 and 1.95±0.64 ml · g^-1 · min^-1 (p<0.01) in territories without ischemia. Conclusion MDCT can be used to quantify MBF using first-pass dynamic data. (Circ J 2008; 72: 1086 - 1091)<br>

Journal

• Circulation Journal

  Circulation Journal 72 (7), 1086-1091, 2008

  The Japanese Circulation Society

Keywords

• Computed tomography (CT)
• Ischemia
• Perfusion

Details

• CRID: 1390282680078692992
• NII Article ID: 110006792060
• NII Book ID: AA11591968
• DOI: 10.1253/circj.72.1086
• ISSN: 13474820
• ISSN: 13469843
• Web Site: http://www.jstage.jst.go.jp/article/circj/72/7/72_7_1086/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008361993
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed