Heat-Treated Mineral-Yeast as a Potent Post-irradiation Radioprotector

• ANZAI Kazunori

  Research Center for Charged Particle Therapy, National Institute of Radiological Sciences

• IKOTA Nobuo

  Research Center for Radiation Emergency Medicine, National Institute of Radiological Sciences

• UENO Megumi

  Research Center for Charged Particle Therapy, National Institute of Radiological Sciences

• NYUI Minako

  Research Center for Charged Particle Therapy, National Institute of Radiological Sciences

• KAGIYA Tsutomu V.

  Health Research Foundation

Abstract

In vivo radioprotection of C3H mice by i.p. administration of Zn-, Mn-, Cu-, or Se-containing heat-treated Saccharomyces serevisiae yeast sample was examined. The 30-day survival of the group treated 30 min before 7.5 Gy whole-body X-irradiation with mineral-containing yeast powders suspended in 0.5% methylcellulose was significantly higher than that of control group. When mineral-yeast was administered immediately after irradiation, the survival rate was even higher and Zn- or Cu-yeast showed the highest rate (more than 90%). Although treatment with simple yeast showed a high survival rate (73%), it was significantly lower than that obtained by the Zn-yeast treatment. The effects of Zn-yeast were studied further. When the interval between irradiation and administration was varied, the protective activity of Zn-yeast decreased gradually by increasing the interval but was still significantly high for the administration at 10 h post-irradiation. The dose reduction factor of Zn-yeast (100 mg/kg, i.p. administration immediately after irradiation) was about 1.2. When the suspension of Zn-yeast was fractionated by centrifugation, the insoluble fraction showed a potent effect, while the soluble fraction had only a moderate effect. In conclusion, mineral-yeast, especially Zn-yeast, provides remarkable post-irradiation protection against lethal whole body X-irradiation. The activity is mainly attributable to the insoluble fraction, whereas some soluble components might contribute to the additional protective activity.

Journal

• Journal of Radiation Research

  Journal of Radiation Research 49 (4), 425-430, 2008

  Journal of Radiation Research Editorial Committee

Keywords

• Radioprotector
• Post-irradiation administration
• Mineral-yeast
• Mice

Details

• CRID: 1390001205216184064
• NII Article ID: 110006820182
• NII Book ID: AA00705792
• DOI: 10.1269/jrr.07127
• COI: 1:STN:280:DC%2BD1cvlsVKjtg%3D%3D
• ISSN: 13499157
• ISSN: 04493060
• ISSN: http://id.crossref.org/issn/04493060
• NDL BIB ID: 9577432
• PubMed: 18480592
• Web Site: http://id.ndl.go.jp/bib/9577432
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9577432
• Web Site: http://academic.oup.com/jrr/article-pdf/49/4/425/6383208/jrr-49-425.pdf
• Web Site: http://dl.ndl.go.jp/info:ndljp/pid/10919075
• Web Site: https://search.jamas.or.jp/link/ui/2009045780
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • NDL-Digital
  • CiNii Articles
• Abstract License Flag: Disallowed