Autologous Bone Marrow-Derived Mononuclear Cell Therapy Prevents the Damage of Viable Myocardium and Improves Rat Heart Function Following Acute Anterior Myocardial Infarction

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Author(s)

    • YIP Hon-Kan
    • Division of Cardiology, Chang Cung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine
    • CHANG Li-Teh
    • Basic Science, Nursing Department, Meiho Institute of Technology
    • WU Chiung-Jen
    • Division of Cardiology, Chang Cung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine
    • SHEU Jiunn-Jye
    • Department of Cardiovascular Surgery, Chang Cung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine
    • PEI Sung-Nan
    • Department of Hematology, Chang Cung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine
    • LEE Fan-Yen
    • Department of Cardiovascular Surgery, Chang Cung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine
    • SUN Cheuk-Kwan
    • Department of General Surgery, Chang Cung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine

Abstract

<b>Background</b> We examined the effects of bone marrow-derived mononuclear cells (BMDMNCs) on preventing viable myocardium damage from myocardial infarction (MI) in a rat MI model. <b>Methods and Results</b> Saline (group 1) or BMDMNCs (group 2) were implanted into the infarct area (IA) of 1-week-old anterior wall MI Sprague - Dawley (SD) rats. Twenty SD rats without MI served as the controls (group 3). The results demonstrated that in remote viable myocardium, the integrated area (μm<sup>2</sup>) of connexin43 spots was lower, whereas the number of apoptotic nuclei were higher in group 1 than in groups 2 and 3 on day 90 following BMDMNC implantation (all p<0.001). Additionally, the number of vessels and survival myocardium in the IA was lower in group 1 than in groups 2 and 3 (all p<0.005). Furthermore, the mRNA expressions of nitric oxide synthase, interleukin-8/Gro-α, interleukin-10 and matrix metalloproteinase-9 were higher in group 2 than in groups 1 and 3 in peri-IA (all p<0.05). On days 42 and 90, the left ventricular (LV) function was lower in group 1 than in groups 2 and 3 (p<0.001). <b>Conclusions</b> Autologous BMDMNC therapy improves LV function, and mitigates molecular and cellular perturbation following MI. (<i>Circ J</i> 2008; <b>72:</b> 1336 - 1345)<br>

Journal

  • Circulation Journal

    Circulation Journal 72(8), 1336-1345, 2008-08-20

    Japanese Circulation Society

References:  37

Cited by:  9

Codes

  • NII Article ID (NAID)
    110006835738
  • NII NACSIS-CAT ID (NCID)
    AA11591968
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13469843
  • Data Source
    CJP  CJPref  NII-ELS  J-STAGE 
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