Pesticide resistance in wild mammals - Mechanisms of anticoagulant resistance in wild rodents -

• Ishizuka Mayumi

  Laboratory of Toxicology, Graduate School of Veterinary Medicine, Hokkaido University

• Tanikawa Tsutomu

  Technical Research Laboratory, Ikari Corporation

• Tanaka Kazuyuki D.

  Laboratory of Toxicology, Graduate School of Veterinary Medicine, Hokkaido University

• Heewon Min

  Laboratory of Toxicology, Graduate School of Veterinary Medicine, Hokkaido University

• Okajima Fumie

  Laboratory of Toxicology, Graduate School of Veterinary Medicine, Hokkaido University

• Sakamoto Kentaro Q.

  Laboratory of Toxicology, Graduate School of Veterinary Medicine, Hokkaido University

• Fujita Shoichi

  Laboratory of Toxicology, Graduate School of Veterinary Medicine, Hokkaido University

抄録

Warfarin is commonly used worldwide as a rodenticide. It inhibits coagulation of blood by inhibiting vitamin K 2,3-epoxide reductase (VKOR) activity. An inadequate supply of vitamin K blocks the production of prothrombin and causes hemorrhage. It has been reported that repeated or long-term treatments with this drug cause resistance in wild rodents. However, the mechanism of warfarin resistance in rodents is still not known precisely. Recent studies reported and identified the function of the molecule, vitamin K epoxide reductase complex subunit 1 (VKORC1), which is the main unit of VKOR. An amino acid substitution in VKORC1 is one of the supposed mechanisms of warfarin resistance. An accelerated detoxification system involving cytochrome P450 (CYP) could also cause the rodenticide resistance. Administration of SKF-525A, a potent inhibitor for P450, increased the mortality due to reduction of warfarin metabolism in warfarin-resistant rats. Meanwhile, the appearance of warfarin-resistant rodents has led to the development of the more effective and toxic rodenticide superwarfarin, which is widely used in Europe and the USA. However, animals resistant to this second-generation rodenticide have already been reported in Europe. In this review, we focus on the mechanism and the pleiotropic effects of pesticide resistance in wild rodents.

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ 33 (3), 283-291, 2008

  一般社団法人　日本毒性学会

キーワード

• Warfarin resistance
• Rodenticide
• Cytochrome P450
• Vitamin K epoxide reductase
• Rodent

詳細情報

• CRID: 1390282679876792704
• NII論文ID: 110006862204
• NII書誌ID: AN00002808
• DOI: 10.2131/jts.33.283
• ISSN: 18803989
• ISSN: 03881350
• NDL書誌ID: 9609101
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9609101
• Web Site: http://www.jstage.jst.go.jp/article/jts/33/3/33_3_283/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2009046094
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可