イソプレン側鎖を有する植物成分の ex vivo 有機合成とその生理活性の評価 [in Japanese] Design, ex vivo Synthesis, and Biological Activities of Plant Constituents Containing an Isoprene Side-chain Based on Isoprenomics [in Japanese]
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Phytyl quinols, namely acyclic tocopherols, are key intermediates of tocopherol biosynthesis,but their biological activities remain unclear. We therefore investigated the structure-activityrelationship of phytyl quinols to apply a chemical biosynthesis design for an antiatherosclerosisdrug based on isoprenomics. We have achieved the biosynthesis-oriented synthesis of α- andβ-phytyl quinol as an unnatural intermediate, other γ- and δ-phytyl quinol as a natural one. All fourphytyl quinols showed almost the same moderate inhibitory activity against low-density lipoproteinoxidation instead of their different degree of C-methylation with character different fromtocopherols. In vivo toxicities of phytyl quinols against chick embryo chorioallantoic membranevasculature were hardly observed. We proposed phytyl quinols were possible antioxidants in plantsand animals, like vitamin E.
- Bulletin of Institute of Technology and Science the University of Tokushima
Bulletin of Institute of Technology and Science the University of Tokushima (53), 52-56, 2008-05-30
The University of Tokushima