Effect of Work Conditions and Work Environments on the Formation of 8-OH-dG in Nurses and Non-Nurse Female Workers

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  • ISHIHARA Itsuko
    Department of Public Health and Occupational Health Nursing, School of Health Sciences, University of Occupational and Environmental Health
  • NAKANO Masahiro
    Department of Health Information Science, School of Health Sciences, University of Occupational and Environmental Health
  • IKUSHIMA Miharu
    Department of Public Health and Occupational Health Nursing, School of Health Sciences, University of Occupational and Environmental Health
  • HARA Yoshiko
    Department of Public Health and Occupational Health Nursing, School of Health Sciences, University of Occupational and Environmental Health
  • YOSHIMINE Toshiko
    Department of Public Health and Occupational Health Nursing, School of Health Sciences, University of Occupational and Environmental Health
  • HARAGA Miki
    Department of Public Health and Occupational Health Nursing, School of Health Sciences, University of Occupational and Environmental Health
  • NAKATANI Junko
    Department of Public Health and Occupational Health Nursing, School of Health Sciences, University of Occupational and Environmental Health
  • KAWAMOTO Rieko
    Kyushu University Faculty of Medical Sciences, Department of Health Sciences, Graduate School of Medical Sciences, Division of Nursing
  • KASAI Hiroshi
    Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health

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Other Title
  • 看護師を含む就労女性の労働態様と尿中8-ヒドロキシデオキシグアノシン（8-OH-dG）排泄量への影響

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Abstract

The purpose of our study was to examine the effects of job stress factors on oxidative DNA injuries among female workers. The levels of urinary 8-hydroxydeoxyguanosine (8-OH-dG) were measured along with a survey on work conditions and environments. The result showed that female workers in shift work excreted increased levels of 8-OH-dG in comparison with the result of those who were engaged in part time work (P<0.01). Moreover, the nurses who marked higher depressive scores excreted significantly increased levels of urinary 8-OH-dG than the nurses who scored lower depressive states. The result revealed a positive correlation between 8-OH-dG levels of nurses in the 35-45 age group and the individual scores of their depressive states (r=0.32, P<0.05). Together, it was suggested that a heavy burden of work in addition to daily domestic roles increases urinary excretion levels of 8-OH-dG.

Journal

  • Journal of UOEH

    Journal of UOEH 30 (3), 293-308, 2008

    The University of Occupational and Environmental Health, Japan

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