Delivery Route in Bone Marrow Cell Transplantation Should be Optimized According to the Etiology of Heart Disease

• Nakajima Hiroyuki

  Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University Department of Cardiovascular Surgery, Mitsubishi Kyoto Hospital

• Sakakibara Yutaka

  Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University

• Tambara Keiichi

  Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University

• Marui Akira

  Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University

• Yoshimoto Momoko

  Department of Pediatrics, Graduate School of Medicine, Kyoto University

• Premaratne Goditha U.

  Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University

• Lin Xue

  Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University

• Kanemitsu Naoki

  Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University

• Sakaguchi Genichi

  Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University

• Ikeda Tadashi

  Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University

• Nishimura Kazunobu

  Department of Cardiovascular Surgery, Tenri Hospital

• Nakahata Tatsutoshi

  Department of Pediatrics, Graduate School of Medicine, Kyoto University

• Komeda Masashi

  Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University

抄録

Background Recent studies have revealed that bone marrow cell (BMC) transplantation is effective not only for myocardial infarction (MI), but also for dilated cardiomyopathy (DCM). However, the method of administering donor cells remains unknown, and may differ between MI and DCM. In the present study, intramyocardial (IM) injection and intravenous (IV) delivery of BMC were compared in each etiological model. Methods and Results MI was induced in 72 mice and DCM in another 36 mice by doxorubicin. BMCs were administered IV or IM in an acute MI (AMI), old MI (OMI) or DCM model. In the AMI model, left ventricular (LV) remodeling was reduced in both the IM- and IV-groups, but only in the IM-group in the OMI model. In the DCM model, the LV dimension of the IV-group was smaller than that of the IM-group. Histological examination showed that green fluorescent protein (GFP) cells were equally distributed in the infarct area of the IV- and IM-groups in AMI, and in the IM-group in the OMI model. In the DCM model, GFP cells were diffusely scattered throughout the ventricular wall in the IV-group, but were confined to the injection site in the IM-group. Conclusions In OMI, IM delivery of BMCs was more effective than IV; however, IV delivery was superior in DCM. Delivery route should be selected according to the etiology of heart disease to optimize the efficacy of BMC transplantation. (Circ J 2008; 72: 1528 - 1535)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 72 (9), 1528-1535, 2008

  一般社団法人 日本循環器学会

キーワード

• Bone marrow cells
• Cardiomyopathy
• Myocardial infarction
• Transplantation

詳細情報

• CRID: 1390001205101834496
• NII論文ID: 110006894393
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-06-0430
• ISSN: 13474820
• ISSN: 13469843
• Web Site: http://www.jstage.jst.go.jp/article/circj/72/9/72_CJ-06-0430/_pdf
• 本文言語コード: en
• データソース種別:
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  • Crossref
  • CiNii Articles
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