Laser Sintering Freeform Fabrication of Highly Porous Tissue Engineering Scaffold

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  • 高空孔率組織工学用担体の粉末焼結積層造形
  • コウクウコウリツ ソシキ コウガクヨウ タンタイ ノ フンマツ ショウケツ セキソウ ゾウケイ

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Abstract

   Fabrication of very porous scaffold for regeneration of organs with high metabolic rate is reported. Polycaprolactone (PCL) powder was mixed with fine grains of sodium chloride as filler and SLS (Selective Laser Sintering) processed to develop an object including fine flow channel network. The object was rinsed with water to desolve the salt, and a high porosity of 90% was successfully obtained. In addition, unsintered powder in the channels was effectively removed owing to disappearance of the filler. Through micro-CT observation, it was confirmed that channels of which diameter was smaller than 1mm were fabricated. Measurement for the amount of residual salt proved that the salt can increase salt concentration of culture media no more than 1% of that for physiological saline solution. It is indicated that excessive sintering, which lowers geometrical resolution of laser sintering process using water leachable inorganic filler, is mainly caused by high speed heat conduction through the filler. Result of culture test is also reported.

Journal

  • SEISAN KENKYU

    SEISAN KENKYU 59 (6), 492-499, 2007

    Institute of Industrial Science The University of Tokyo

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