循環血液中の肝臓特異的mRNA測定による肝臓傷害検出法の有用性

DOI 日本農学文献記事索引 Web Site Web Site 被引用文献1件 参考文献27件
  • KUDO Yuka
    Discovery Biology 3, Discovery Biology Research, Pfizer Global Research and Development Nagoya Laboratories, Pfizer Japan Inc.
  • OCHI Takashi
    Discovery Biology 3, Discovery Biology Research, Pfizer Global Research and Development Nagoya Laboratories, Pfizer Japan Inc.
  • SHIMADA Hideaki
    Discovery Biology 3, Discovery Biology Research, Pfizer Global Research and Development Nagoya Laboratories, Pfizer Japan Inc.
  • OGAWA Shinji
    Discovery Biology 3, Discovery Biology Research, Pfizer Global Research and Development Nagoya Laboratories, Pfizer Japan Inc.
  • SHINJO Katsuhiro
    Discovery Biology 3, Discovery Biology Research, Pfizer Global Research and Development Nagoya Laboratories, Pfizer Japan Inc.

書誌事項

タイトル別名
  • Utility of Plasma Circulating mRNA as a Marker to Detect Hepatic Injury
  • Toxicology: Utility of plasma circulating mRNA as a marker to detect hepatic injury

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Utility of plasma circulating mRNA as a molecular marker to detect hepatic injury was evaluated. Total RNA was isolated from plasma of the rat liver fibrosis models at various time points, and plasma circulating mRNAs of major liver-derived genes, albumin and haptoglobin, were measured by real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). Sensitivity and kinetics of plasma circulating mRNA were compared with those of plasma alanine aminotransferase (ALT) activity. We have found that the measurement of plasma circulating mRNA is more sensitive than plasma ALT activity, and enables early detection of hepatic injury. The plasma circulating mRNA will serve as a novel and highly sensitive molecular marker for hepatic injury.<br>

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