Comparative study of histamine H4 receptor expression in human dermal fibroblasts

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Author(s)

    • Shiba Kayoko SHIBA Kayoko
    • Department of Geriatric Pharmacology & Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University
    • Ohki Emi [他] OHKI Emi
    • Department of Geriatric Pharmacology & Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University
    • MUTOH Nanami
    • Department of Geriatric Pharmacology & Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University
    • SUZUKI Masahiko
    • Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University
    • SATO Hiromi
    • Department of Geriatric Pharmacology & Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University
    • UENO Koichi
    • Department of Geriatric Pharmacology & Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University

Abstract

The histamine H4 receptor (H4R) is the newest receptor identified of four histamine receptors. Its expression in numerous immune and inflammatory organs has been implicated in relation to immune systems and allergic diseases. In the present study, we demonstrate the expression of H4R in human dermal fibroblasts and investigate changes in its expression level when stimulated by histamine, phorbol 12-myristate 13-acetate (PMA), lipopolysaccharides (LPS), dexamethasone and indomethacin. Histamine and PMA showed no effects on H4R expression. LPS and indomethacin up-regulated H4R mRNA expression, and 20 µM dexamethasone increased H4R protein levels. These results indicate a good prospective for this new receptor in the development of effective treatments of inflammatory diseases and pruritus or for the appropriate prevention of toxicities.

Journal

  • The Journal of Toxicological Sciences

    The Journal of Toxicological Sciences 33(4), 503-508, 2008-10-01

    The Japanese Society of Toxicology

References:  17

Cited by:  4

Codes

  • NII Article ID (NAID)
    110006950531
  • NII NACSIS-CAT ID (NCID)
    AN00002808
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    03881350
  • NDL Article ID
    9672195
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z19-1022
  • Data Source
    CJP  CJPref  NDL  NII-ELS  J-STAGE 
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