Comparative study of histamine H4 receptor expression in human dermal fibroblasts

• Ikawa Yoshiko

  Department of Geriatric Pharmacology & Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University,

• Shiba Kayoko

  Department of Geriatric Pharmacology & Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University,

• Ohki Emi

  Department of Geriatric Pharmacology & Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University,

• Mutoh Nanami

  Department of Geriatric Pharmacology & Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University,

• Suzuki Masahiko

  Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University

• Sato Hiromi

  Department of Geriatric Pharmacology & Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University,

• Ueno Koichi

  Department of Geriatric Pharmacology & Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University,

Abstract

The histamine H4 receptor (H4R) is the newest receptor identified of four histamine receptors. Its expression in numerous immune and inflammatory organs has been implicated in relation to immune systems and allergic diseases. In the present study, we demonstrate the expression of H4R in human dermal fibroblasts and investigate changes in its expression level when stimulated by histamine, phorbol 12-myristate 13-acetate (PMA), lipopolysaccharides (LPS), dexamethasone and indomethacin. Histamine and PMA showed no effects on H4R expression. LPS and indomethacin up-regulated H4R mRNA expression, and 20 µM dexamethasone increased H4R protein levels. These results indicate a good prospective for this new receptor in the development of effective treatments of inflammatory diseases and pruritus or for the appropriate prevention of toxicities.

Journal

• The Journal of Toxicological Sciences

  The Journal of Toxicological Sciences 33 (4), 503-508, 2008

  The Japanese Society of Toxicology

Keywords

• Histamine H4 receptor
• Dermal fibroblast
• Indomethacin
• Dexamethasone

Details

• CRID: 1390282679879470720
• NII Article ID: 110006950531
• NII Book ID: AN00002808
• DOI: 10.2131/jts.33.503
• COI: 1:CAS:528:DC%2BD1cXht1Omtr%2FL
• ISSN: 18803989
• ISSN: 03881350
• NDL BIB ID: 9672195
• PubMed: 18827451
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9672195
• Web Site: http://www.jstage.jst.go.jp/article/jts/33/4/33_4_503/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2009089223
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed