Efficacy and Safety of Ivermectin for Scabies in Six Patients in Mental Hospital
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- Nakamura Seiji
- Sakamoto Hospital,Department of Pharmacy
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- Morita Emiko
- Sakamoto Hospital,Department of Pharmacy
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- Kimura Sadae
- Sakamoto Hospital,Department of Pharmacy
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- Sadamoto Yumi
- Sakamoto Hospital,Department of Pharmacy
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- Ueno Masatugu
- Sakamoto Hospital,Department of Pharmacy
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- Iwai Reiko
- Sakamoto Hospital,Department of Pharmacy
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- Ikushima Shinobu
- Sakamoto Hospital,Department of Internal medicine
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- Hirokawa Yoshihiro
- Sakamoto Hospital,Department of Psychatry
Bibliographic Information
- Other Title
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- 精神科病院で集団発生した疥癬6症例のイベルメクチンの有用性と使用上の留意点
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Abstract
Scabies is a major form of dermatitis and in the second edition of clinical management guidelines for scabies drawn up by a committee of the Japanese Dermatological Association in 2007,ivermectin was recommended as a drug of choice for its treatment.Ivermectin had been approved as a treatment for scabies and launched in Japan in August 2006.<br>On administering ivermection to 6 patients who developed scabies in our geriatric mental ward,3 of them subsequently developed hepatic function disorders.In order to investigate the cause of these disorders,we examined their weights,ages,drug interactions,and metabolism.<br>We found that blood levels of ivermectin were easily affected by fat in the diet due to its liposolubility.In addition,since CYP3A4,an enzyme considered to be involved in the metabolism of ivermectin,may increase the toxicity of its metabolic products,we concluded that use of ivermectin should be reviewed.It is recommended that hepatic function tests are carried out a week before and after administering ivermectin,and that it should be given at bedtime to avoid drug interactions.
Journal
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- Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)
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Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) 34 (10), 938-942, 2008
Japanese Society of Pharmaceutical Health Care and Sciences
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Keywords
Details 詳細情報について
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- CRID
- 1390001204777720704
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- NII Article ID
- 110006950690
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- NII Book ID
- AA11527197
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- ISSN
- 18821499
- 1346342X
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- NDL-Digital
- CiNii Articles
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- Abstract License Flag
- Disallowed