Identifying Novel Polymorphisms in the Canine Tryptophan Hydroxylase 2 Gene
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- KANEKO Fumihiro
- Laboratory of Veterinary Ethology, The University of Tokyo
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- MASUDA Koji
- Laboratory of Veterinary Ethology, The University of Tokyo
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- TAKEUCHI Yukari
- Laboratory of Veterinary Ethology, The University of Tokyo
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- MORI Yuji
- Laboratory of Veterinary Ethology, The University of Tokyo
Bibliographic Information
- Other Title
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- Ethology: Identifying novel polymorphisms in the canine Tryptophan Hydroxylase 2 gene
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Abstract
Tryptophan hydroxylase (TPH) serves as the rate-limiting enzyme in the biosynthesis of serotonin, and two forms of TPH genes, TPH1 and TPH2, have been reported with specific nucleotide sequences and expression patterns. We determined the sequences of these two genes and identified polymorphisms within their coding regions. We identified five novel single nucleotide polymorphisms in the TPH2 gene, one of which resulted in a non-synonymous mutation and the remaining four in synonymous mutations. Comparison of the genotype frequencies of the polymorphisms among five popular breeds with different behavioral traits revealed statistically significant interbreed differences for three polymorphisms. These results suggest that these polymorphisms would be useful genetic markers when performing behavior studies in dogs.<br>
Journal
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- Journal of Veterinary Medical Science
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Journal of Veterinary Medical Science 70 (10), 1117-1120, 2008
JAPANESE SOCIETY OF VETERINARY SCIENCE
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Keywords
Details 詳細情報について
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- CRID
- 1390282681406371200
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- NII Article ID
- 110006967098
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- NII Book ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL BIB ID
- 9691738
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed