Effects of 3-Methyl-4-nitrophenol on the Reproductive Toxicity in Female Japanese Quail (Coturnix japonica)

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Author(s)

    • Li ChunMei LI ChunMei
    • Environmental Nanotoxicology Section, Research Center for Environmental Risk, National Institute for Environmental Studies
    • TANEDA Shinji
    • Environmental Nanotoxicology Section, Research Center for Environmental Risk, National Institute for Environmental Studies
    • WATANABE Gen
    • Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
    • TAYA Kazuyoshi
    • Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology

Abstract

We previously showed that 3-methyl-4-nitrophenol (4-nitro-<i>m</i>-cresol, PNMC), a component of diesel exhaust particles and a degradation product of the insecticide fenitrothion, has reproductive toxicity in adult male and immature female Japanese quail (<i>Coturnix japonica</i>). Here we investigated effects of PNMC on the reproductive toxicity of mature female Japanese quail. The experiment consists of 3 periods of pretreatment, treatment, and post-treatment for 5 d each. The birds were reared, bred naturally for 1 week, and after 5 d of pretreatment, then injected intramuscularly with PNMC at doses 1, 10, or 100 mg/kg body weight daily for 5 d. Body weight, egg weight, and hatchability did not differ among the observation periods. However, at all doses of PNMC, the egg-laying rate showed a modest decrease during the treatment period, with recovery during the post-treatment period. Plasma concentrations of luteinizing hormone (LH) and estrodiol-17β, were significantly decreased (<i>p</i><0.05), and plasma concentrations of progesterone significantly increased (<i>p</i><0.05) in birds treated with 10 and 100 mg/kg PNMC. These results suggest that PNMC have acute toxicity, and inhibited LH secretion, disturbing egg-laying in mature female quail. Our findings indicate that PNMC induces endocrine malfunction at the central level and subsequently disrupts reproductive processes in mature female quails.

Journal

  • Biological and Pharmaceutical Bulletin

    Biological and Pharmaceutical Bulletin 31(11), 2158-2161, 2008-11-01

    The Pharmaceutical Society of Japan

References:  26

Cited by:  1

Codes

  • NII Article ID (NAID)
    110006968106
  • NII NACSIS-CAT ID (NCID)
    AA10885497
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    09186158
  • NDL Article ID
    9685864
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-V41
  • Data Source
    CJP  CJPref  NDL  NII-ELS  J-STAGE 
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