Latent Essential Fatty Acid Deficiency in a Special Diet Deteriorates Skin Barrier

• Ishina, Ko

• Kobayashi, Hiromi

• Tsuruta, Daisuke

• Wakamatsu, Kanae

• Hasegawa, Junichi

• Ishii, Masamitsu

抄録

Background : Recently, a new atopic dermatitis (AD) mouse model was reported; after feeding hairless mice with a special low magnesium diet (HR-AD), they developed dry skin (low skin water content and high transepidermal water loss (TEWL)) and elevated blood immunoglobulin E levels (IgE) with 100% repeatability. Therefore, this model was used for therapeutic research regarding AD. However, to determine the mechanism by which HR-AD induces AD-like symptoms, the relationships between low magnesium, essential fatty acids (EFA), and lipid composition need to be clarified. / Methods : First, to clarify whether the low magnesium of HR-AD induces AD-like symptoms, hairless mice were fed HR-AD or magnesium-supplemented HR-AD....

収録刊行物

• Osaka City Medical Journal

  Osaka City Medical Journal 54 (2), 63-74, 2008-12

  OSAKA CITY MEDICAL ASSOCIATION

キーワード

• Atopic dermatitis
• Animal model
• Essential fatty acids
• Transepidermal water loss

詳細情報

• CRID: 1050282677424493312
• NII論文ID: 110006980454
• NII書誌ID: AA00765896
• ISSN: 00306096
• Web Site: https://dlisv03.media.osaka-cu.ac.jp/il/meta_pub/G0000438repository_00306096-54-2-63
• Web Site: https://search.jamas.or.jp/link/ui/2009159107
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles