The Effects of Low-Dose Pergolide on the Valves of the Heart in Japanese Patients

• Kouno, Yasushi

• Takemoto, Yasuhiko

• Shimada, Hiroyuki

• Negishi, Kazuaki

• Miki, Takami

• Yoshiyama, Minoru

Abstract

Background : High-dose pergolide has been reported to induce valvular heart disease. It has not been fully determined whether valvular heart disease is elicited by low-dose pergolide, similar to high-dose pergolide in Japanese patients. / Methods : Fifty-two consecutive patients (20 males, mean age 70±7 years) with Parkinson's disease were enrolled in our study. Twenty-three patients had been treated with low-dose pergolide (less than 1.5 mg/day) before enrollment. Of these 23 patients, 8 had been treated with pergolide and L-dopa without other ergot-derived dopamine receptor agonists (OE) and defined as the pergolide group without OE (P without OE). Fifteen patients had been treated with pergolide, L-dopa, and OE and defined as the pergolide group with OE (P with OE). The other 29 patients had not been treated with pergolide. Of these 29 patients, ...

Journal

• Osaka City Medical Journal

  Osaka City Medical Journal 54 (2), 103-109, 2008-12

  OSAKA CITY MEDICAL ASSOCIATION

Keywords

• Parkinson's disease
• Valvular heart disease
• Ergot-derived dopamine receptor agonists Pergolide
• L-dopa

Details

• CRID: 1050001202450107264
• NII Article ID: 110006980458
• NII Book ID: AA00765896
• ISSN: 00306096
• Web Site: https://dlisv03.media.osaka-cu.ac.jp/il/meta_pub/G0000438repository_00306096-54-2-103
• Web Site: https://search.jamas.or.jp/link/ui/2009159111
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles