Gender Differences in Chronic Thromboembolic Pulmonary Hypertension in Japan

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Author(s)

    • SHIGETA Ayako
    • Department of Respirology, Graduate School of Medicine, Chiba University
    • TANABE Nobuhiro
    • Department of Respirology, Graduate School of Medicine, Chiba University
    • SHIMIZU Hidefumi
    • Department of Respirology, Graduate School of Medicine, Chiba University
    • HOSHINO Susumu
    • Department of Respirology, Graduate School of Medicine, Chiba University
    • MARUOKA Miki
    • Department of Respirology, Graduate School of Medicine, Chiba University
    • SAKAO Seiichiro
    • Department of Respirology, Graduate School of Medicine, Chiba University
    • TADA Yuji
    • Department of Respirology, Graduate School of Medicine, Chiba University
    • TAKIGUCHI Yuichi
    • Department of Respirology, Graduate School of Medicine, Chiba University
    • TATSUMI Koichiro
    • Department of Respirology, Graduate School of Medicine, Chiba University

Abstract

<b>Background</b> The predominance of chronic thromboembolic pulmonary hypertension (CTEPH) in females and association of HLA-B*5201 with CTEPH have been reported in Japan. However, the clinical characteristics of female CTEPH remain uncertain. The purpose of the present study is to clarify the clinical phenotype of female CTEPH in Japan. <b>Methods and Results</b> The 150 consecutive patients (female 103, male 47; age 52.8±12.4 years SD) were admitted to Chiba University Hospital, and diagnosis was confirmed using right cardiac catheterization and pulmonary angiography. Among these patients, 78 underwent pulmonary endarterectomy. Clinical characteristics, pulmonary hemodynamics, extent of central disease and surgical outcome in females were compared with those in males. The female patients were elderly and had less deep vein thrombosis, less acute embolic episodes, better cardiac function, lower arterial oxygen tension and more peripheral thrombi, and showed less improvement through surgery than males. When the patients were identified using HLA-B*5201, HLA-B*5201-positive female patients had less embolic episodes and better cardiac function with lower operative mortality. In contrast, HLA-B*5201-negative female patients had less embolic episodes, and more peripheral thrombi, resulting in less improvement by surgery. <b>Conclusion</b> The clinical phenotype of female CTEPH differed from that of male CTEPH. Additionally, gender differences of HLA-B*5201-positive type were dissimilar to those of HLA-B*5201-negative type. (<i>Circ J</i> 2008; <b>72:</b> 2069 - 2074)<br>

Journal

  • Circulation Journal

    Circulation Journal 72(12), 2069-2074, 2008-12-20

    Japanese Circulation Society

References:  31

Cited by:  2

Codes

  • NII Article ID (NAID)
    110006987366
  • NII NACSIS-CAT ID (NCID)
    AA11591968
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13469843
  • Data Source
    CJP  CJPref  NII-ELS  J-STAGE 
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