Influence of Adipocytokines on Differentiation of Pro-osteoblastic Cells
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- KAMADA Aiko
- Departments of Biochemistry, Osaka Dental University, Osaka, Japan
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- IKEO Takashi
- Departments of Biochemistry, Osaka Dental University, Osaka, Japan
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- YOSHIKAWA Yoshihiro
- Departments of Biochemistry, Osaka Dental University, Osaka, Japan
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- DOMAE Eisuke
- Departments of Biochemistry, Osaka Dental University, Osaka, Japan
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- GODA Seiji
- Departments of Biochemistry, Osaka Dental University, Osaka, Japan
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- TAMURA Isao
- Departments of Biochemistry, Osaka Dental University, Osaka, Japan
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- KON-I Hirotaka
- Division for Interdisciplinary Dentistry for Postgraduate Trainee, Osaka Dental University, Osaka, Japan
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- OKAZAKI Joji
- Department of Geriatric Dentistry, Osaka Dental University, Osaka, Japan
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- KAWAMOTO Akiyo
- Department of Geriatric Dentistry, Osaka Dental University, Osaka, Japan
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- KOMASA Yutaka
- Department of Geriatric Dentistry, Osaka Dental University, Osaka, Japan
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- TODA Isumi
- Department of Anatomy, Osaka Dental University, Osaka, Japan
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- SUWA Fumihiko
- Department of Anatomy, Osaka Dental University, Osaka, Japan
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抄録
Adipocytokines are a group of adipocyte-derived biologically active molecules, including adiponectin, leptin, tumor necrosis factor-α (TNF-α), resistin. A proteolytic cleavage product of adiponectin/Acrp30, gAcrp30, is found to circulate in plasma and to have a three-dimensional structure similar to that of TNF-α. In this study, we demonstrated the expression of adiponectin receptors in cultured pro-osteoblastic cells, and investigated the influences of gAcrp30 and TNF-α on osteoblast differentiation.<br>RT-PCR analysis demonstrated the expression of transcripts for both adiponectin receptors, AdipoR1 and AdipoR2, in murine pro-osteoblastic cell line, MC3T3-E1. Both gAcrp30 and TNF-α suppressed mRNA levels of type I collagen and RANKL compared with time-matched controls. Interestingly, gAcrp30 had no significant influence on the promotion of osteocalcin expression induced by the stimulation of ascorbic acid and β-glycerophosphate, although TNF-α inhibited the increase of osteocalcin expression.<br>These results indicated that adiponectin may not affect osteoblast differentiation but may suppress osteoclastogenesis in an endocrine manner, while TNF-α may inhibit the differentiation of pro-osteoblastic cells.
収録刊行物
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- Journal of Oral Tissue Engineering
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Journal of Oral Tissue Engineering 6 (1), 17-23, 2008
日本再生歯科医学会
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詳細情報 詳細情報について
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- CRID
- 1390001205224919680
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- NII論文ID
- 110007004835
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- NII書誌ID
- AA1195240X
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- ISSN
- 18800823
- 13489623
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可